MPhil Ocular Oncology

Overview

Professor Sarah Coupland is a Lead of the Liverpool Ocular Oncology Research Group (LOORG), Professor Sarah Coupland is a Consultant Histopathologist and the George Holt Chair of Pathology, University of Liverpool. She is also the Director of the North West Cancer Research Centre-University of Liverpool. The group focuses clinical on molecular genetics of cancers with particular interests in uveal melanoma; conjunctival melanoma; intraocular and ocular adnexal lymphomas.

Research themes

ITEM: CR-UK funded multicentre single arm phase II study of imatinib in good performance status patients with c-kit positive metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

SUAVE: CR-UK funded multicentre randomised phase II study of sunitinib in good performance status patients with metastatic uveal melanoma. Associated biosamples collected for translational purposes include; blood samples, formalin fixed paraffin embedded tissue blocks of the metastatic lesions and matched primary tumours (where available).

Our research themes include:

• Uveal melanoma
• Conjunctival melanoma
• Intraocular and ocular adnexal lymphomas
• CNS lymphoma.

Our reserach interests include:

• The role of tumour stem cells in uveal melanoma development and progression
• Identification of regulators of metastasis
• Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets.